- 影响因子：
0.0
- 发表刊物：
Cell host & microbe
- 摘要：
In the absence of pathogen infection, plant effector-triggered immune (ETI) receptors are maintained in a preactivation state by intermolecular interactions with other host proteins. Pathogen effector-induced alterations activate the receptor. In Arabidopsis, the ETI receptor RPM1 is activated via bacterial effector AvrB-induced phosphorylation of the RPM1-interacting protein RIN4 at Threonine 166. We find that RIN4 also interacts with the prolyl-peptidyl isomerase (PPIase) ROC1, which is reduced upon RIN4 Thr166 phosphorylation. ROC1 suppresses RPM1 immunity in a PPIase-dependent manner. Consistent with this, RIN4 Pro149 undergoes cis/trans isomerization in the presence of ROC1. While the RIN4(P149V) mutation abolishes RPM1 resistance, the deletion of Pro149 leads to RPM1 activation in the absence of RIN4 phosphorylation. These results support a model in which RPM1 directly senses conformational changes in RIN4 surrounding Pro149 that is controlled by ROC1. RIN4 Thr166 phosphorylation indirectly regulates RPM1 resistance by modulating the ROC1-mediated RIN4 isomerization.
- 论文编号：
48
- 卷号：
16
- 期号：
4
- 页面范围：
473-483
- 是否译文：
否
- 发表时间：
2014-10-08
- 收录刊物：
SCI
- 发布期刊链接：
- 第一作者：
Li M
- 通讯作者：
Zhou J,Liu D,Zhao Y,Dong L
- 全部作者：
Coaker G,Xia Bin,Shen QH,Yu Y,Zhang L,Li X,Ding P,Yadeta KA,Chiang YH,Ma X
