Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases
- 影响因子：
0.0
- 发表刊物：
Chemistryan Asian journal
- 关键字：
DNA methylation; DNA/RNA repair; demethylases; dioxygenases; epigenetics; non-heme iron
- 摘要：
DNA/RNA methylation can be generated by methyltransferases and thus plays a critical role in regulating cellular processes; alternatively, nucleic acid methylation can be produced by methylation agents and is cytotoxic/mutagenic if left unrepaired. Oxidative demethylation mediated by non-heme iron-dependent dioxygenases is an efficient way to reverse either the cellular roles of regulatory methylation or the cytotoxic/mutagenic effects of methylation damage. In this Focus Review we summarize recent advances in the study of nucleic acid dioxygenases exemplified by the TET and AlkB family proteins, with an emphasis on chemical insights from the recent literature. Comparison of the chemical mechanisms of these dioxygenases revealed that differences in the mechanism also contribute significantly to their distinct biological functions
- 论文类型：
期刊论文
- 论文编号：
47
- 卷号：
9
- 期号：
8
- 页面范围：
2018-2029
- 是否译文：
否
- 发表时间：
2014-08-09
- 收录刊物：
SCI
- 发布期刊链接：
- 第一作者：
Lu L
- 通讯作者：
Yi C
- 全部作者：
Xia Bin,Zhu C
