A Novel Bcl-XL Inhibitor Z36 that Induces Autophagic Cell Death in Hela Cells
影响因子：
0.0
发表刊物：
Autophagy
摘要：
Inhibition of Bcl2 family proteins Bcl-X(L) and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-X(L) inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not apoptosis. This special property distinguishes Z36 from other previously reported Bcl-X(L) and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis, and makes Z36 an attractive molecular tool for studying the cellular regulation of autophagic cell death and apoptosis.
论文类型：
期刊论文
论文编号：
16
卷号：
5
期号：
3
是否译文：
否
发表时间：
2009-04-01
第一作者：
Lin J
通讯作者：
Xia Bin
全部作者：
Lin S,Jin C,Chen Y,Sheng F,Wang L,Liu S,Wang N,Xiao J,Ren X,Zhao F,Tian S,Zhong W,Yu W,Li Y,Zheng Z
