The heme oxygenase-1 inhibitor ZnPPIX induces non-canonical, Beclin 1-independent, autophagy through p38 MAPK pathway
- 影响因子：
0.0
- DOI码：
10.1093/abbs/gms064
- 发表刊物：
Acta Biochim Biophys Sin (Shanghai)
- 摘要：
Zinc protoporphyrin IX (ZnPPIX), a heme oxygenase-1 enzyme inhibitor, has been reported to induce apoptosis and to have antitumor properties. Here, we report that ZnPPIX triggers autophagy and causes defective autophagy flux in HeLa cells. Autophagosome formation was independent of Beclin 1, indicating non-canonical autophagy activity in ZnPPIX-treated cells. Furthermore, western blot results indicated that p38 MAPK (mitogen-activated protein kinase) was phosphorylated in treated cells. Consistently, SB203580 (a p38 inhibitor) obviously inhibited the accumulation of autophagosomes. Our results indicated that p38 MAPK may be a key regulator for non-canonical Beclin1-independent autophagy.
- 论文编号：
36
- 是否译文：
否
- 发表时间：
2012-01-01
- 发布期刊链接：
- 第一作者：
Zhou C
- 通讯作者：
Lin J,Deng X
- 全部作者：
Xia Bin,Zhu H,Sheng F,Zhou J
