Silencing of foreign DNA in bacteria
- 影响因子：
0.0
- DOI码：
10.1016/j.mib.2011.12.014
- 发表刊物：
Curr Opin Microbiol
- 摘要：
Xenogeneic silencing proteins facilitate horizontal gene transfer by silencing expression of AT-rich sequences. By virtue of their activity these proteins serve as master regulators of a variety of important functions including motility, drug resistance, and virulence. Three families of silencers have been identified to date: the H-NS like proteins of Gram-negative bacteria, the MvaT like proteins of Pseudomonacae, and the Lsr2 proteins of Actinobacteria. Structural and biochemical characterization of these proteins have revealed that they share surprising commonalities in mechanism and function despite extensive divergence in both sequence and structure. Here we discuss the mechanisms that underlie the ability of these proteins to selectively target AT-rich DNA and the contradictory data regarding the mode by which H-NS forms nucleoprotein complexes
- 论文编号：
33
- 卷号：
15
- 页面范围：
175-81
- 是否译文：
否
- 发表时间：
2012-01-01
- 发布期刊链接：
- 第一作者：
Ali SS
- 通讯作者：
Navarre WW
- 全部作者：
Liu J,Xia Bin
