Activation and Maturation of SARS-CoV Main Protease
- 影响因子:
0.0
- DOI码:
10.1007/s13238-011-1034-1
- 发表刊物:
Protein Cell
- 摘要:
The worldwide outbreak of the severe acute respiratory syndrome (SARS) in 2003 was due to the transmission of SARS coronavirus (SARS-CoV). The main protease (M(pro)) of SARS-CoV is essential for the viral life cycle, and is considered to be an attractive target of anti-SARS drug development. As a key enzyme for proteolytic processing of viral polyproteins to produce functional non-structure proteins, M(pro) is first auto-cleaved out of polyproteins. The monomeric form of M(pro) is enzymatically inactive, and it is activated through homo-dimerization which is strongly affected by extra residues to both ends of the mature enzyme. This review provides a summary of the related literatures on the study of the quaternary structure, activation, and self-maturation of M(pro) over the past years.
- 论文编号:
30
- 卷号:
2
- 页面范围:
282-90
- 是否译文:
否
- 发表时间:
2011-01-01
- 发布期刊链接:
- 第一作者:
Kang X
- 通讯作者:
Xia Bin